Risk Factors in Development of Vulvar Intraepithelial Neoplasia (VIN)

Risk Factors in Development of Vulvar Intraepithelial Neoplasia (VIN)

The VIN prevalence in the society is around 2.0 in 100,000. 75% of the patients are 50 years of age and under and the average occurrence is 46 (van Seters M., van Beurden M., de Craen A.J. Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients. Gynecol. Oncol. 2005;97(2):645).

Typical risk factors for VIN: HPV infection, smoking and immunosuppressor diseases (cancer, dialysis patients, HIV carriers and patients taking immunosuppressant drugs for a reason etc.).

90% of all typical VIN cases HPV infection is detected (van de Nieuwenhof HP, van der Avoort IA. Et al. Review of squamous premalignant vulvar lesions. Crit Rev Oncol Hematol. 2008;68(2):131-136).

All these structures with the same origin are affected with same events including infectious diseases. Thus HPV infection causes the formation of displasic cells in all these structures. In 60% of patients detected with VIN 3 VAIN (Vaginal intraepithelial neoplasia) 3 or CIN (Cervical intraepithelial neoplasia) 3 is detected too.

”. All these structures with the same origin are affected with same events including infectious diseases. Thus HPV infection causes the formation of displasic cells in all these structures. In 60% of patients detected with VIN 3 VAIN (Vaginal intraepithelial neoplasia) 3 or CIN (Cervical intraepithelial neoplasia) 3 is detected too.

In a similar fashion in 3% of the cases detected with CIN 3 VAIN and in 7% of them VIN 3 is found (Hørding U, Junge J, Poulsen H. et al. Vulvar intraepithelial neoplasia III: a viral disease of undetermined progressive potential. Gynecol Oncol. 1995;56(2):276).

**The above 2 paragraphs shall be repeated in the texts of the site because I believe it is an information that should be known by you, the patients, fighting with this disease.

Even though the relation between smoking and VIN is not clearly known there is a very close relation. The patients detected with VIN and smoking should definitely quit to get rid of the disease.

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